Psychopharmacology: A humanized monoclonal antibody attenuates fentanyl self-administration and reverses and prevents fentanyl-induced ventilatory depression in rhesus monkeys
Galbo-Thomma LK, Marecki C, Kim CM, Hiranita T, Taylor JR, Maguire DR, Hicks D, Gebo A, Khaimraj A, Baehr C, Pravetoni M, France CP. Psychopharmacology (Berl). 2025 Feb 5. doi: 10.1007/s00213-025-0675 ...
ACS Omega: Structure-Based Engineering of Monoclonal Antibodies for Improved Binding to Counteract the Effects of Fentanyl and Carfentanil
Rodarte J, Baehr C, Hicks D, McGovern M, Zhang Y, Silva-Ortiz P, Hannon B, Duddu S, Pancera M, Pravetoni M. ACS Omega. 2024 Oct 7;9(41):42506-42519. doi: 10.1021/acsomega.4c06617. PMID: 39431098
The Journal of Immunology: Monoclonal Antibodies Engineered with Fc Region Mutations to Extend Protection against Fentanyl Toxicity
Khaimraj A, Baehr CA, Hicks D, Raleigh MD, Pravetoni M. J Immunol. 2024 Sep 1;213(5):663-668. doi: 10.4049/jimmunol.2400170. PMID: 39018496
Expert Opinion Investigational Drugs: The potential role of opioid vaccines and monoclonal antibodies in the opioid overdose crisis
Martinez S, Harris H, Chao T, Luba R, Pravetoni M, Comer SD, Jones JD. Expert Opin Investig Drugs. 2023 Mar;32(3):181-185. doi: 10.1080/13543784.2023.2187286. PMID: 36863002
Structure: Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding
Rodarte JV, Baehr C, Hicks D, Liban TL, Weidle C, Rupert PB, Jahan R, Wall A, McGuire AT, Strong RK, Runyon S, Pravetoni M, Pancera M. Structure. 2023 Jan 5;31(1):20-32.e5. doi: 10.1016/j.str.2022.11. ...
Human Vaccines & Immunotherapeutics: Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development
Hicks D, Baehr C, Silva-Ortiz P, Khaimraj A, Luengas D, Hamid FA, Pravetoni M. Hum Vaccin Immunother. 2022 Nov 30;18(6):2122507. doi: 10.1080/21645515.2022.2122507. PMID: 36194773
The Journal of Pharmacology and Experimental Therapeutics: Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity
Baehr CA, Wu MM, Pandit SG, Arias-Umana J, AuCoin D, Pravetoni M. J Pharmacol Exp Ther. 2022 May;381(2):129-136. doi: 10.1124/jpet.121.001048. PMID: 35153198
The Journal of Pharmacology and Experimental Therapeutics: Monoclonal Antibodies Counteract Opoid-Induced Behavioral and Toxic Effects in Mice and Rats
Baehr C, Kelcher AH, Khaimraj A, Reed DE, Pandit SG, AuCoin D, Averick S, Pravetoni M. J Pharmacol Exp Ther. 2020 Dec;375(3):469-477. doi: 10.1124/jpet.120.000124. PMID: 32980813